In the crypto world, opportunities for high-multiplier growth are often concentrated in niche sectors with explosive growth from 0 to 1 and strong narratives.

Based on market trends at the end of 2025 and technological forecasts for 2026, the following three sectors are most likely to generate excess returns: AI Agents and automated settlement (AI + Crypto), which are highly favored by institutions for this “closed-loop logic.”

In 2026, AI agents will truly live on the chain, possessing independent wallets (such as KYA identities supported by the x402 protocol), autonomously optimizing yields, handling micro-payments, or participating in prediction markets.

High-multiplier opportunity: tokens focused on on-chain infrastructure dedicated to AI, where micro-payments from massive Agents will drive value capture.

RWA (Real World Assets) full tokenization will shape the “OnFi” (On-Chain Finance) era in 2026. With clearer regulations like the US GENIUS/CLARITY acts, traditional assets will be tokenized on a large scale.

Breakout point: not only US debt tokenization but also high-yield private credit and fragmented physical assets (such as real estate and carbon credits).

High-multiplier opportunity: protocols that connect with institutions like BlackRock and Visa. Once endorsed, liquidity and valuation will grow exponentially.

DePIN (Decentralized Physical Infrastructure Networks) will enter the “hardware delivery” harvest period in 2026, attracting outside industrial capital and having strong cross-sector appeal.

Breakout point: decentralized computing power (supporting AI inference) and energy/sensor networks, providing a cheap alternative to centralized cloud services.

High-multiplier opportunity: small-cap projects with low hardware barriers and existing B-end clients. 53 webpage